(S)-2-Cyano-piperidine-1-carboxylic acid tert-butyl ester
1-Piperidinecarboxylicacid, 2-cyano-, 1,1-dimethylethyl ester, (2S)-
CAS: 242459-44-5
Molecular Formula: C11H18N2O2
(S)-2-Cyano-piperidine-1-carboxylic acid tert-butyl ester - Names and Identifiers
(S)-2-Cyano-piperidine-1-carboxylic acid tert-butyl ester - Physico-chemical Properties
| Molecular Formula | C11H18N2O2 |
| Molar Mass | 210.27 |
| Density | 1.07 |
| Boling Point | 325.3±35.0 °C(Predicted) |
| Flash Point | 150.5 °C |
| pKa | -4.85±0.40(Predicted) |
| Storage Condition | 2-8°C |
(S)-2-Cyano-piperidine-1-carboxylic acid tert-butyl ester - Introduction
1-Piperidinecarboxylicacid, 2-cyano-, 1,1-dimethylethyl ester, (2S)-, also known as 2-cyano-(1,1-dimethylethyl) 1-piperidinecarboxylic acid ester, (2S)-. The following is an introduction to its nature, use, preparation and safety information:
Nature:
1-Piperidinecarboxylicacid, 2-cyano-, 1,1-dimethylethyl ester, (2S)-is a white to off-white solid, soluble in common organic solvents such as ethanol, dimethylformamide and dichloromethane. It has a melting point of about 40-42 ° C. And is stable in air.
Use:
1-Piperidinecarboxylicacid, 2-cyano-, 1,1-dimethylethyl ester, (2S)-is a commonly used organic synthesis intermediate. It can be used to synthesize various drugs and compounds, such as anticancer drugs, antidepressant drugs and bioactive molecules. It is often used as a chiral acid or chiral catalyst in organic synthesis reactions. In addition, it can also be used to synthesize other organic molecules, such as plant hormones and pesticides.
Method:
The preparation method of 1-Piperidinecarboxylicacid, 2-cyano-, 1,1-dimethylethyl ester, (2S)-is relatively simple. It is usually prepared by acylation of (R)-( )-2-cyanopiperidine with (Boc)2O. The specific procedure is as follows: (R)-( )-2-cyanopiperidine is reacted with (Boc)2O in a suitable solvent, usually at low temperature. The solid product is then filtered and purified by appropriate crystallization to obtain the desired product.
Safety Information:
1-Piperidinecarboxylicacid, 2-cyano-, 1,1-dimethylethyl ester, (2S)-is a chemical that should be operated under safe conditions. It may cause irritation to the eyes, skin and respiratory system, so appropriate safety measures should be taken when handling, such as wearing protective glasses, gloves and respiratory protection. In addition, it should be stored in a dry, cool and well-ventilated place, away from high temperatures, open flames and oxidants.
Nature:
1-Piperidinecarboxylicacid, 2-cyano-, 1,1-dimethylethyl ester, (2S)-is a white to off-white solid, soluble in common organic solvents such as ethanol, dimethylformamide and dichloromethane. It has a melting point of about 40-42 ° C. And is stable in air.
Use:
1-Piperidinecarboxylicacid, 2-cyano-, 1,1-dimethylethyl ester, (2S)-is a commonly used organic synthesis intermediate. It can be used to synthesize various drugs and compounds, such as anticancer drugs, antidepressant drugs and bioactive molecules. It is often used as a chiral acid or chiral catalyst in organic synthesis reactions. In addition, it can also be used to synthesize other organic molecules, such as plant hormones and pesticides.
Method:
The preparation method of 1-Piperidinecarboxylicacid, 2-cyano-, 1,1-dimethylethyl ester, (2S)-is relatively simple. It is usually prepared by acylation of (R)-( )-2-cyanopiperidine with (Boc)2O. The specific procedure is as follows: (R)-( )-2-cyanopiperidine is reacted with (Boc)2O in a suitable solvent, usually at low temperature. The solid product is then filtered and purified by appropriate crystallization to obtain the desired product.
Safety Information:
1-Piperidinecarboxylicacid, 2-cyano-, 1,1-dimethylethyl ester, (2S)-is a chemical that should be operated under safe conditions. It may cause irritation to the eyes, skin and respiratory system, so appropriate safety measures should be taken when handling, such as wearing protective glasses, gloves and respiratory protection. In addition, it should be stored in a dry, cool and well-ventilated place, away from high temperatures, open flames and oxidants.
Last Update：2024-04-09 20:52:54
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CAS: 242459-44-5
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Mobile: 18021002903
QQ: 3008007409
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CAS: 242459-44-5
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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